Journal: Nature Communications

Article Title: Light-driven liquid metal nanotransformers for biomedical theranostics

doi: 10.1038/ncomms15432

Figure Lengend Snippet: ( a ) Vial containing an aqueous suspension of LM nanocapsules (LM concentration: 115 μg ml −1 ). ( b ) TEM image of LM nanocapsules. Scale bar, 200 nm. ( c ) Ultraviolet–visible–NIR absorbance spectrum of LM nanocapsules (LM concentration: 500 μg ml −1 ). ( d ) Cell viability following treatment with various nanomaterials. SWCNT, single-walled carbon nanotube; MWCNT, multi-walled carbon nanotube; Au-NR1, methyl-terminated-hydrophilic polymer-conjugated gold nanorod; Au-NR2, methoxy-PEG 2000 -SH modified gold nanorod. Error bars represent s.d.'s of five separate measurements. *N.D.: not determined because all of cells were dead. The standardized percentage of mitochondrial enzyme activity compared with control. Statistical analyses were performed using ANOVA (Tukey's test). a P <0.0005; b P <0.9; c P <0.05. ( e ) Viability and ( f ) body weight of the mice ( N =5) following the injection of LM nanocapsules observed for 19 days. Data represent the mean of five determinations; error bars show the s.d. a P <1; b P <0.2; c P <0.07.

Article Snippet: DSPE-PEG 2000 -Amine-SWCNT and DSPE-PEG 2000 -Amine-MWCNT were synthesized as follows: SWCNT (CoMoCAT CG300, purity>95%, average diameter and length: 0.6–1.1 nm and 0.1–1.0 μm, respectively; SouthWest NanoTechnologies, Norman, OK, USA) (10 mg) or MWCNT (Nanocyl 3,100, purity>95%, average diameter 9.5 nm, average length 1.5 μm; Nanocyl, Belgium) (10 mg) were mixed with DSPE-PEG 2000 -Amine (10 mg) in water (10 ml) for 10 min by pulse sonication.

Techniques: Suspension, Concentration Assay, Polymer, Modification, Activity Assay, Control, Injection

Journal: Naunyn-Schmiedeberg's Archives of Pharmacology

Article Title: Pharmacokinetic study of tianeptine and its active metabolite MC5 in rats following different routes of administration using a novel liquid chromatography tandem mass spectrometry analytical method

doi: 10.1007/s00210-017-1448-2

Figure Lengend Snippet: Metabolic pathways for tianeptine

Article Snippet: Tianeptine sodium salt (purity ≥ 95%) was obtained from Cayman Chemical Company (USA), tianeptine metabolite MC5 sodium salt (purity ≥ 95%) was obtained from Toronto Research Chemicals (Canada).

Techniques:

Journal: Naunyn-Schmiedeberg's Archives of Pharmacology

Article Title: Pharmacokinetic study of tianeptine and its active metabolite MC5 in rats following different routes of administration using a novel liquid chromatography tandem mass spectrometry analytical method

doi: 10.1007/s00210-017-1448-2

Figure Lengend Snippet: Product ion mass spectra of [M + H + ] + ions of tianeptine ( a ), metabolite MC5 ( b ), and IS ( c ) with the proposed fragmentation paths

Article Snippet: Tianeptine sodium salt (purity ≥ 95%) was obtained from Cayman Chemical Company (USA), tianeptine metabolite MC5 sodium salt (purity ≥ 95%) was obtained from Toronto Research Chemicals (Canada).

Techniques:

Journal: Naunyn-Schmiedeberg's Archives of Pharmacology

Article Title: Pharmacokinetic study of tianeptine and its active metabolite MC5 in rats following different routes of administration using a novel liquid chromatography tandem mass spectrometry analytical method

doi: 10.1007/s00210-017-1448-2

Figure Lengend Snippet: Representative chromatogram of QC sample at the LLOQ concentration (1 ng/mL). a Tianeptine. b Metabolite MC5. c Internal standard. d Blank sample

Article Snippet: Tianeptine sodium salt (purity ≥ 95%) was obtained from Cayman Chemical Company (USA), tianeptine metabolite MC5 sodium salt (purity ≥ 95%) was obtained from Toronto Research Chemicals (Canada).

Techniques: Concentration Assay

Journal: Naunyn-Schmiedeberg's Archives of Pharmacology

Article Title: Pharmacokinetic study of tianeptine and its active metabolite MC5 in rats following different routes of administration using a novel liquid chromatography tandem mass spectrometry analytical method

doi: 10.1007/s00210-017-1448-2

Figure Lengend Snippet: Within-day and between-days accuracy (% of nominal concentration) and precision (%RSD) of tianeptine and MC5 in rat plasma ( n = 5)

Article Snippet: Tianeptine sodium salt (purity ≥ 95%) was obtained from Cayman Chemical Company (USA), tianeptine metabolite MC5 sodium salt (purity ≥ 95%) was obtained from Toronto Research Chemicals (Canada).

Techniques: Concentration Assay, Clinical Proteomics

Journal: Naunyn-Schmiedeberg's Archives of Pharmacology

Article Title: Pharmacokinetic study of tianeptine and its active metabolite MC5 in rats following different routes of administration using a novel liquid chromatography tandem mass spectrometry analytical method

doi: 10.1007/s00210-017-1448-2

Figure Lengend Snippet: Back-calculated plasma concentrations of calibrators for tianeptine and metabolite MC5 ( n = 5)

Article Snippet: Tianeptine sodium salt (purity ≥ 95%) was obtained from Cayman Chemical Company (USA), tianeptine metabolite MC5 sodium salt (purity ≥ 95%) was obtained from Toronto Research Chemicals (Canada).

Techniques: Clinical Proteomics, Concentration Assay

Journal: Naunyn-Schmiedeberg's Archives of Pharmacology

Article Title: Pharmacokinetic study of tianeptine and its active metabolite MC5 in rats following different routes of administration using a novel liquid chromatography tandem mass spectrometry analytical method

doi: 10.1007/s00210-017-1448-2

Figure Lengend Snippet: Serum pharmacokinetic parameters calculated from concentration vs. time data ( n = 3) of tianeptine and MC5 metabolite determined by non-compartmental analysis after a single intravenous or intraperitoneal administration of tianeptine to rats at a dose of 1 or 10 mg/kg, respectively. Data are presented as geometric mean (GM), 90% confidence interval (CI), and coefficient of variation (CV)

Article Snippet: Tianeptine sodium salt (purity ≥ 95%) was obtained from Cayman Chemical Company (USA), tianeptine metabolite MC5 sodium salt (purity ≥ 95%) was obtained from Toronto Research Chemicals (Canada).

Techniques: Concentration Assay

Journal: Naunyn-Schmiedeberg's Archives of Pharmacology

Article Title: Pharmacokinetic study of tianeptine and its active metabolite MC5 in rats following different routes of administration using a novel liquid chromatography tandem mass spectrometry analytical method

doi: 10.1007/s00210-017-1448-2

Figure Lengend Snippet: Measured (symbols) and pharmacokinetic model predicted (lines) concentration versus time profiles of tianeptine and its metabolite MC5 following intravenous ( a ) and intraperitoneal ( b ) administration of the parent drug to rats at the doses of 1 and 10 mg/kg, respectively

Article Snippet: Tianeptine sodium salt (purity ≥ 95%) was obtained from Cayman Chemical Company (USA), tianeptine metabolite MC5 sodium salt (purity ≥ 95%) was obtained from Toronto Research Chemicals (Canada).

Techniques: Concentration Assay

Journal: Naunyn-Schmiedeberg's Archives of Pharmacology

Article Title: Pharmacokinetic study of tianeptine and its active metabolite MC5 in rats following different routes of administration using a novel liquid chromatography tandem mass spectrometry analytical method

doi: 10.1007/s00210-017-1448-2

Figure Lengend Snippet: The perfusate concentration-time profile of tianeptine in the isolated perfused rat liver (mean ± SD; n = 3) after a single dose administration of the drug (300 μg)

Article Snippet: Tianeptine sodium salt (purity ≥ 95%) was obtained from Cayman Chemical Company (USA), tianeptine metabolite MC5 sodium salt (purity ≥ 95%) was obtained from Toronto Research Chemicals (Canada).

Techniques: Concentration Assay, Isolation

Journal: Naunyn-Schmiedeberg's Archives of Pharmacology

Article Title: Pharmacokinetic study of tianeptine and its active metabolite MC5 in rats following different routes of administration using a novel liquid chromatography tandem mass spectrometry analytical method

doi: 10.1007/s00210-017-1448-2

Figure Lengend Snippet: Mass spectra of rat bile sample scanned in the PI (precursor ion) 292 mode. M / z 437.7 — tianeptine; M1—metabolite MC3; M2—metabolite MC5; M3 and M4—conjugates of tianeptine with glutamine and glucuronic acid, respectively; M5 and M6—conjugates of metabolite MC5 with glutamine and glucuronic acid, respectively

Article Snippet: Tianeptine sodium salt (purity ≥ 95%) was obtained from Cayman Chemical Company (USA), tianeptine metabolite MC5 sodium salt (purity ≥ 95%) was obtained from Toronto Research Chemicals (Canada).

Techniques: